Serum CYR61 Is Associated with Disease Activity in Graves' Orbitopathy
Young Jun Woo1, Yuri Seo1, Jin Joo Kim1
1a Institute of Vision Research, Department of Ophthalmology , Yonsei University College of Medicine , Seoul , South Korea.
Purpose:
To investigate the clinical implications of cysteine-rich angiogenic inducer 61 (CYR61) in Graves' orbitopathy (GO).
Methods:
Sera from 52 GO patients, 23 Graves' disease (GD) patients, and 20 healthy controls, and orbital fat tissue samples from 12 of 52 GO patients and 8 control subjects were included for analysis. Concentrations of CYR61 were measured from sera with an enzyme-linked immunosorbent assay, and CYR61 mRNA expression levels were evaluated from orbital fat tissue with polymerase chain reaction.
Results:
Serum CYR61 levels were higher in GO patients than in controls (p = 0.001). Patients with active GO showed higher CYR61 levels than those with inactive GO (p < 0.001) or GD (p = 0.004). Expression of CYR61 mRNA was 7.4-fold higher in patients with GO than in healthy controls (p < 0.001).
Conclusions:
CYR61 could be an adjuvant biomarker associated with the inflammatory activity of GO.
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