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Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
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Immunological Characteristics of Colitis Associated with Anti-CTLA-4 Antibody Therapy

Giorgos Bamias1, Ioanna Delladetsima2, Marina Perdiki2

  • 1a Academic Department of Gastroenterology, School of Medicine , National and Kapodistrian University of Athens, Laiko General Hospital , Athens , Greece.

Cancer Investigation
|May 27, 2017
PubMed

Anti-CTL4-A therapy is associated with development of colitis. We characterized ipilimumab-associated colitis in nine melanoma patients (6 male, mean age: 55.3-yrs). Median value for diarrhea grade was 2, number of ipilimumab doses 2, and interval since last administration 3-wks. Endoscopic characteristics resembled inflammatory bowel disease and histology revealed predominance of plasmacytes or CD4+ T-cells. We observed significant upregulation of Th1 and Th17 effector pathways (>10-fold increase for IFN-γmRNA, >5-fold for IL-17A, p < 0.01 vs. controls). Significant elevation of FoxP3 was also detected. In conclusion, ipilimumab administration results in elevations of effector lymphocytes and pro-inflammatory mediators in the gut lamina propria.

Keywords:
ColitisImmunology/immunobiologyIpilimumabLate effects of therapyMonoclonal antibodies

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