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The Adverse Effect of the 2-1-1 Regimen for Rabies PEP in Preschool Children
Shu Qing Liu1, Xiao Yan Tao1, Peng Cheng Yu1
1Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Insights
The Essen regimen is recommended for rabies post-exposure prophylaxis (PEP) in preschool children. This rabies prevention strategy showed fewer febrile reactions compared to the 2-1-1 regimen in young children.
Area of Science:
- Pediatric Infectious Diseases
- Vaccinology
- Public Health
Background:
- Post-exposure prophylaxis (PEP) is crucial for rabies prevention and control.
- Limited data exists on adverse reactions to Essen and 2-1-1 rabies PEP regimens in preschool children (0-6 years).
Abstract:
Post-exposure prophylaxis (PEP) has proved to be the most important measure for rabies prevention and control. There is little information regarding adverse reactions to the Essen and 2-1-1 regimens in preschool children (aged 0-6). We reexamined the outcomes of 1,109 preschool children who were vaccinated using SPEEDA under the Essen regimen between January 2011 and December 2012 and 1,267 preschool children under the 2-1-1 regimen between January 2013 and December 2014. We find that, in preschool children, the febrile reaction after the first 2-dose injection in the 2-1-1 regimen was significantly higher than that induced by the first 1-dose in the Essen procedure. Thus, we recommend that the Essen regimen should still be used for rabies PEP in preschool children.
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