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A Filter-based Surface Enhanced Raman Spectroscopic Assay for Rapid Detection of Chemical Contaminants
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A recyclable silver ions-specific surface-enhanced Raman scattering (SERS) sensor.

Dan Sun1, Guohua Qi1, Fanghao Cao2

  • 1State Key Laboratory of Supramolecular Structure and Materials, Institute of Theoretical Chemistry, Jilin University, Changchun 130012, PR China.

Talanta
|May 29, 2017
PubMed
Summary
This summary is machine-generated.

A novel surface-enhanced Raman scattering (SERS) chip sensor uses glucose oxidase (GOD) for highly sensitive and selective detection of silver ions. This recyclable sensor shows promise for in vivo silver ion tracing.

Keywords:
Glucose oxidaseReusabilitySensorSilver ionSurface-enhanced Raman scattering

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Area of Science:

  • Analytical Chemistry
  • Materials Science
  • Biochemistry

Background:

  • Silver ions (Ag+) are environmental pollutants and essential biological trace elements.
  • Accurate detection of Ag+ is crucial for environmental monitoring and biological studies.
  • Existing detection methods often lack sensitivity, selectivity, or recyclability.

Purpose of the Study:

  • To develop a highly sensitive and recyclable surface-enhanced Raman scattering (SERS) chip sensor for silver ion determination.
  • To utilize glucose oxidase (GOD) as a novel SERS probe for Ag+ detection.
  • To explore the potential of the sensor for in vivo applications.

Main Methods:

  • Fabrication of a SERS-active chip by layer-by-layer assembly of GOD on metal nanoparticles.
  • Utilizing the specific reversible binding between Ag+ and the iso-alloxazine in GOD.
  • Monitoring spectral variations in SERS for quantitative Ag+ detection.
  • Regenerating the sensor by reducing bound Ag(I) to Ag(0) using sodium borohydride.

Main Results:

  • The developed SERS chip sensor demonstrated high sensitivity and selectivity for Ag+.
  • A low detection limit of 1.0×10-10 M for Ag+ was achieved.
  • The sensor exhibited excellent recyclability due to the reversible binding and regeneration mechanism.
  • GOD acted as both an Ag+ binder and a SERS signal reporter, simplifying the sensor design.

Conclusions:

  • The GOD-based SERS chip sensor offers a promising platform for sensitive and selective Ag+ detection.
  • The sensor's recyclability and nontoxic nature make it suitable for biological applications.
  • This technology holds potential for in vivo tracing of silver ions.