1,4-Benzothiazines-A Biologically Attractive Scaffold
Amit Rai1, Ashok K Singh1, Vinit Raj1
1Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow-226025, India.
Mini Reviews in Medicinal Chemistry
|May 30, 2017
Summary
1,4-benzothiazines are versatile heterocyclic compounds with diverse biological activities, particularly in cancer regulation. This review details their synthesis, activities, and structure-activity relationships for future research.
Area of Science:
- Medicinal Chemistry
- Organic Chemistry
- Pharmacology
Background:
- 1,4-benzothiazine (1,4-B) is a key pharmacophore in antipsychotic phenothiazine drugs.
- This heterocyclic compound class exhibits a wide range of biological activities.
Purpose of the Study:
- To systematically review synthetic strategies for 1,4-benzothiazine analogues.
- To summarize the biological activities and structure-activity relationships (SAR) of 1,4-benzothiazines.
- To highlight the potential of 1,4-benzothiazines in cancer regulation.
Main Methods:
- Literature review of synthetic routes for 1,4-benzothiazine derivatives.
- Compilation of reported biological activities and SAR data.
- Analysis of structure-activity relationships through comparison with parent 1,4-B derivatives.
Main Results:
- Numerous synthetic routes for diverse 1,4-benzothiazine analogues have been developed.
- These analogues demonstrate significant biological activities via multiple mechanisms.
- Structure-activity relationship studies reveal key modifications for enhanced efficacy.
Conclusions:
- 1,4-benzothiazines possess significant potential for regulating various types of cancer.
- This review provides a comprehensive overview to guide future research in 1,4-benzothiazine chemistry and applications.
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