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Cerebellum: Anatomical Regions01:17

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The main and largest component of the human brain is the cerebrum. The cerebrum consists of two main parts: the cerebral cortex, an outer layer with wrinkles or folds known as gyri and shallow grooves called sulci, and a deeper region beneath it. The cerebrum divides into two distinct hemispheres and contains five different lobes: the frontal, parietal, temporal, occipital, and insula. The central sulcus separates the frontal and parietal lobes and two functionally important gyri — the...
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Cerebrum: Anatomical Overview II01:11

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Related Experiment Video

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Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model
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Brainstem and cerebellar cavernous malformations.

Gursant S Atwal1, Christina E Sarris1, Robert F Spetzler1

  • 1Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.

Handbook of Clinical Neurology
|May 30, 2017
PubMed
Summary

Cavernous malformations, or brain vascular anomalies, can cause various neurological symptoms. Management depends on lesion location, patient presentation, and surgical risks.

Keywords:
central nervous systemcranial neuropathydevelopmental venous anomaliesinfratentorial lesionsintracranial cavernous malformationssupratentorial lesions

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Area of Science:

  • Neurology
  • Neurosurgery
  • Vascular Medicine

Background:

  • Cavernous malformations are central nervous system vascular lesions, frequently supratentorial.
  • They can be sporadic or familial, often associated with developmental venous anomalies.
  • Infratentorial lesions more commonly cause focal neurologic deficits.

Purpose of the Study:

  • To review the clinical presentation, natural history, and management of cavernous malformations.
  • To highlight the importance of lesion location and patient factors in treatment decisions.

Main Methods:

  • Review of existing literature on cavernous malformations.
  • Analysis of clinical presentations, diagnostic methods, and treatment outcomes.

Main Results:

  • Cavernous malformations present with headaches, seizures, or focal deficits.
  • Increasing MRI use leads to more incidental discoveries.
  • Both observation and surgical resection are viable treatment options.

Conclusions:

  • Understanding the natural history of cavernous malformations is crucial for effective management.
  • Treatment decisions require careful consideration of clinical presentation, lesion location, and surgical risk assessment.