Related Experiment Video
Updated: Mar 1, 2026
07:27
Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
Published on: October 6, 2016
11.0K
Aging with HIV in the ART era
Emma Kaplan-Lewis1, Judith A Aberg1, Mikyung Lee1
1Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1090, New York, NY 10029, USA.
Seminars in Diagnostic Pathology
|May 30, 2017
Summary
People with HIV are living longer, but face more health issues like inflammation and traditional risk factors. This review highlights current comorbidities in people with HIV (PLWH) for better awareness.
Area of Science:
- Infectious Diseases
- Immunology
- Public Health
Background:
- Modern HIV therapy significantly increases life expectancy for people living with HIV (PLWH).
- Prolonged survival is linked to increased comorbidities due to chronic inflammation, immune activation, and senescence in PLWH.
- Factors like substance use, viral hepatitis co-infection, and cardiovascular risks exacerbate comorbidities.
Purpose of the Study:
- To review current comorbidities in people living with HIV (PLWH).
- To raise awareness of conditions that may be overlooked in younger PLWH.
- To inform healthcare providers about the evolving health landscape of PLWH.
Main Methods:
- Literature review of recent studies on comorbidities in PLWH.
- Analysis of factors contributing to increased comorbidity prevalence.
- Synthesis of data on common and emerging health conditions.
Main Results:
- PLWH experience a higher prevalence of comorbidities compared to the general population.
- Chronic inflammation and immune dysregulation are key drivers of these conditions.
- Traditional cardiovascular risk factors are significantly elevated in PLWH.
Conclusions:
- Increased awareness and proactive management of comorbidities are crucial for PLWH.
- Healthcare strategies must adapt to address the complex health needs of aging PLWH.
- Further research is needed to optimize long-term care and outcomes for PLWH.
More Related Videos
Related Concept Videos
01:10Retrovirus Life Cycles
50.0K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
50.0K
01:26Sexually Transmitted Infections
1.4K
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
1.4K
01:29Pulmonary Tuberculosis I
1.1K
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.1K
01:26Aging
913
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
913
01:19The Effect of Aging on Tissues
4.0K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
4.0K
01:25Immunodeficiency Diseases
2.7K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
2.7K