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Related Concept Videos

Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

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In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
538
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

397
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
397
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

544
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
544
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

533
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
533
Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant01:25

Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant

286
In patients with renal disease, dosage adjustments are necessary to maintain therapeutic plasma drug concentrations and prevent toxicity or subtherapeutic exposure. Renal impairment alters drug pharmacokinetics, especially in conditions like uremia, where changes such as prolonged elimination half-life and altered apparent volume of distribution can significantly affect drug disposition. These changes require careful modification of the dosing regimen to achieve the desired clinical...
286
Urinary Tract Calculi IV: Nutrition Therapy and Prevention01:27

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

489
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
489

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Updated: Mar 1, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
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Considering renal risk while managing cancer.

Vahakn B Shahinian1, Amit Bahl2, Daniela Niepel3

  • 1Department of Internal Medicine, Kidney Epidemiology and Cost Center, University of Michigan, Ann Arbor, MI, USA.

Cancer Management and Research
|May 30, 2017
PubMed
Summary
This summary is machine-generated.

Cancer patients often face kidney problems due to age, disease, and treatments. Nephrologists are crucial for managing renal function and protecting kidneys from nephrotoxic cancer therapies.

Keywords:
advanced cancercancer managementelderlykidney diseasenephrotoxicityrenal function

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Area of Science:

  • Oncology and Nephrology
  • Cancer and Kidney Disease Interactions

Background:

  • Reciprocal relationship exists between cancer and chronic kidney disease.
  • Cancer patients frequently experience renal impairment from various factors.
  • Improving cancer therapies lead to longer survival, increasing risk of long-term complications.

Purpose of the Study:

  • To review the relationship between cancer and kidney disease.
  • To examine treatments impacting kidney function in cancer patients.
  • To discuss considerations for monitoring renal function.

Main Methods:

  • Literature review on cancer-kidney interactions.
  • Analysis of nephrotoxic cancer treatments and their effects.
  • Discussion of monitoring strategies for renal function.

Main Results:

  • Cancer and kidney disease have a bidirectional relationship.
  • Nephrotoxic treatments (chemotherapy, antibiotics, bone agents) can harm kidneys.
  • Age, disease factors, and treatments contribute to renal impairment in cancer patients.

Conclusions:

  • Nephrologists play a vital role in managing renal impairment in cancer patients.
  • Collaboration between oncologists and nephrologists is essential for optimal care.
  • Kidney protection strategies are needed for patients receiving nephrotoxic therapies.