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Related Experiment Videos

A Toolbox for Optophysiological Experiments in Freely Moving Rats.

Stefanie Hardung1,2,3, Mansour Alyahyay2,3, David Eriksson2,3

  • 1Ernst Strüngmann Institute gGmbHFrankfurt, Germany.

Frontiers in Systems Neuroscience
|May 30, 2017
PubMed
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This study evaluates devices for simultaneous neural recordings and optogenetic manipulation in rats. All tested devices enable chronic in vivo optophysiology, aiding researchers entering the field.

Area of Science:

  • Neuroscience
  • Optogenetics
  • Animal Behavior

Background:

  • Simultaneous neural circuit recording and manipulation is crucial in modern neuroscience.
  • Optogenetics has enabled combined neural readout and optogenetic write-in probes.
  • Device selection depends on animal model, brain region, and behavioral readout.

Purpose of the Study:

  • To provide an overview of devices for chronic simultaneous neural recordings and optogenetic manipulation in awake behaving rats.
  • To compare custom-made and commercially available devices for in vivo optophysiology.
  • To aid researchers in selecting appropriate equipment for combined neural recording and optogenetic control.

Main Methods:

  • Evaluation of four devices: two fixed arrays and two movable drives.
Keywords:
electrode/wire arraysextracellular recordingsmicrodrivesoptogeneticsrat model system

Related Experiment Videos

  • Testing both custom-made (in-house) and commercially available options.
  • Assessment of recording quality and probe features for chronic implantation.

    • Main Results:

    • All four tested devices demonstrated feasibility for simultaneous neural recordings and optogenetic manipulations.
    • Detailed data on recording quality and comparative probe features are presented.
    • Evidence supports the effectiveness of these devices for in vivo optophysiology.

    Conclusions:

    • Simultaneous neural recording and optogenetic manipulation are achievable with the evaluated devices.
    • The study offers practical guidance on equipment and building procedures for in vivo optophysiology.
    • This overview assists researchers in cost-effective implementation of combined neural readout and optogenetic control.