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A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
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Sickle cell disease and implementation science: A partnership to accelerate advances
Allison A King1,2,3,4, Ana A Baumann5
1Program in Occupational Therapy, Washington University School of Medicine, St. Louis, Missouri.
Pediatric Blood & Cancer
|May 31, 2017
Summary
Implementation science can accelerate the adoption of evidence-based treatments for sickle cell disease (SCD). This approach aims to reduce the gap between medical advances and their availability to patients, improving outcomes for those with SCD.
Area of Science:
- Health Services Research
- Translational Science
Background:
- Sickle cell disease (SCD) causes significant end-organ damage and reduces lifespan.
- Patient outcomes in SCD are influenced by disease pathophysiology and social determinants of health.
Purpose of the Study:
- To discuss the role of implementation science in addressing challenges within sickle cell disease care.
- To emphasize the necessity of implementation science for faster integration of evidence-based practices.
Main Methods:
- Review of existing literature on medical advances in SCD.
- Analysis of barriers to clinical practice penetration for new SCD treatments.
Main Results:
- Randomized controlled trials have yielded medical advancements for SCD.
- The time lag in translating research into clinical practice limits patient benefit.
Conclusions:
- Implementation science offers a framework to expedite the delivery of evidence-based care in SCD.
- Adopting implementation science strategies is crucial for improving clinical outcomes and shortening the timeline for patient access to effective treatments.
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