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Red cell enzymes and plasma protein polymorphisms in the population of Cabo Verde (West Africa)

E J Parra1, J C Teixeira Ribeiro2, A Riveiro1

  • 1Departamento de Antropoloxía, Facultade de Bioloxía, Universidade de Santiago, 15706 Santiago de Compostela, Galicia, Spain.

American Journal of Human Biology : the Official Journal of the Human Biology Council
|May 31, 2017
PubMed

Insights

Genetic analysis of red cell enzymes and plasma proteins in Cabo Verde reveals intermediate frequencies between African and European populations. This suggests significant European contribution to the West African gene pool.

Area of Science:

  • Population Genetics
  • Human Genetics
  • Biochemistry

Background:

  • The population of Cabo Verde, founded in the 15th century, has a unique demographic history.
  • It was established by West African slaves and European settlers, primarily Portuguese.

Purpose of the Study:

  • To analyze the genetic polymorphism of red cell enzymes and plasma proteins in the Cabo Verdean population.
  • To determine the genetic contribution of African and European ancestries.

Main Methods:

  • Analysis of genetic polymorphism for six red cell enzymes (ADA, AK1, ALAD, ESD, GLO1, PGD).
  • Analysis of genetic polymorphism for ten plasma proteins (AHSG, BF, F13A, F13B, GC, HP, ORM, PLG, TBG, TF).
  • Study conducted on 268 unrelated individuals from Cabo Verde.

Main Results:

  • Allele frequencies for most markers were intermediate between African and European populations.
  • Specific alleles, rare in Africans but common in Europeans, were identified.
  • This indicates a mixed genetic heritage in the Cabo Verdean population.

Conclusions:

  • The genetic profile of Cabo Verdeans reflects a substantial European admixture.
  • The study highlights the complex genetic makeup resulting from historical population movements.

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