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Updated: Mar 1, 2026

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Induced Cell Turnover: A Novel Therapeutic Modality for In Situ Tissue Regeneration

Francesco Albert Bosco Cortese1,2, Sebastian Aguiar3, Giovanni Santostasi4

  • 11 Biogerontology Research Foundation, Oxford, United Kingdom .

Human Gene Therapy
|May 31, 2017
PubMed

Insights

Induced cell turnover (ICT) offers a novel approach to tissue regeneration by removing damaged cells and replacing them with stem cells. This method could enable in situ repair for non-transplantable tissues, advancing regenerative medicine.

Area of Science:

  • Regenerative Medicine
  • Cell Therapy
  • Tissue Engineering

Background:

  • Induced cell turnover (ICT) is a theoretical strategy for tissue repair.
  • It involves targeted removal of damaged cells and replacement with new ones.
  • Current limitations hinder its clinical application.

Purpose of the Study:

  • To outline strategies for overcoming barriers to induced cell turnover.
  • To stimulate research at the intersection of cell therapy, tissue engineering, and regenerative medicine.
  • To explore ICT as an alternative to ex vivo organ transplantation.

Main Methods:

  • Tissue-specific ablation using pro-apoptotic agents or suicide gene therapy.
  • Cell replenishment via systemic administration or controlled release from biomaterials.
  • Engineering cells for homing, robustness, and enhanced function.

Main Results:

  • The article theoretically outlines complementary strategies for ICT implementation.
  • It addresses challenges in ablation and cell replacement for in situ regeneration.
  • Potential applications include non-transplantable tissues like vasculature and nervous system.

Conclusions:

  • ICT presents a promising theoretical framework for in situ tissue regeneration.
  • Addressing current barriers could enable ICT for various non-transplantable tissues.
  • Further research is crucial to translate ICT into clinical practice.
Keywords:
biomedical gerontologycell therapygeroscienceregenerative medicinestem cellstissue engineering

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