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[Hepatocellular carcinoma].
C S Gonçalves1, F E Pereira, M da P Zago
1Departamento da Clínica Médica e de Patologia do Centro Biomédico da Universidade Federal do Espírito Santo e Serviços de Gastroenterologia e de Patologia do Hospital Universitário Cassiano Antonio de Moraes, Vitória, ES.
Arquivos De Gastroenterologia
|October 1, 1988
Summary
Hepatocellular carcinoma (HCC), a global health concern, is strongly linked to the hepatitis B virus (HBV). Early diagnosis and HBV vaccination are key to reducing the incidence of this common liver cancer.
Area of Science:
- Hepatology
- Oncology
- Virology
Context:
- Hepatocellular carcinoma (HCC) is a significant global public health issue, particularly in high-incidence regions like Africa and Southeast Asia.
- The World Health Organization recognizes HCC as a major health concern.
- HCC is frequently associated with liver cirrhosis.
Purpose:
- To review the multifaceted aspects of Hepatocellular Carcinoma (HCC).
- To explore the etiology, geographic distribution, morphology, clinical presentation, and diagnosis of HCC.
- To discuss therapeutic strategies and prevention through Hepatitis B Virus (HBV) vaccination.
Summary:
- HCC is closely linked to the hepatitis B virus (HBV), though other carcinogens also contribute to its development.
- The review covers geographic variations in HCC incidence, morphological classifications, and clinical/biochemical diagnostic methods, including alpha-fetoprotein and ultrasonography.
- Early diagnosis in high-risk patients and the role of HBV vaccination in reducing HCC incidence are emphasized.
Impact:
- Highlights the critical role of HBV in HCC pathogenesis and the importance of vaccination for prevention.
- Emphasizes the need for improved early diagnostic methods, such as ultrasonography, for HCC.
- Provides insights into HCC classification and management, relevant for clinicians and public health officials.