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Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Related Experiment Video

Updated: Mar 1, 2026

Robust Generation of Hepatocyte-like Cells from Human Embryonic Stem Cell Populations
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Robust Generation of Hepatocyte-like Cells from Human Embryonic Stem Cell Populations

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Stem cells: the new "model organism".

David G Drubin1, Anthony A Hyman2

  • 1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3202 drubin@berkeley.edu.

Molecular Biology of the Cell
|June 1, 2017
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Summary
This summary is machine-generated.

Advances in genome editing, stem cell technology, and organoid development are revolutionizing cell biology. These innovations enhance the study of basic cellular mechanisms and disease understanding using human tissue models.

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Area of Science:

  • Molecular and Cell Biology
  • Biotechnology
  • Genomics

Background:

  • Human tissue culture cells are crucial for research but often lack natural physiological function.
  • Limitations of traditional cell cultures hinder understanding of complex biological processes.

Purpose of the Study:

  • To highlight the revolutionary impact of combined advances in genome editing, stem cell production, and organoid derivation.
  • To emphasize the implications for basic cell biology and disease mechanism translation.

Main Methods:

  • Integration of advanced genome editing techniques.
  • Development of novel stem cell production protocols.
  • Derivation of organoids from stem cells for physiological relevance.

Main Results:

  • These combined technologies offer a paradigm shift in cell biology research.
  • Enhanced models provide greater physiological accuracy compared to traditional cell cultures.
  • Improved understanding of fundamental cell mechanisms and disease pathologies.

Conclusions:

  • The convergence of these technologies marks a new era in biological research.
  • These advancements facilitate more accurate translation of basic science discoveries to clinical applications.
  • Future research will benefit from more physiologically relevant human cell models.