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Psychosis and dementia: risk factor, prodrome, or cause?
Corinne E Fischer1, Luis Agüera-Ortiz2
1Keenan Research Centre for Biomedical Research,Li Ka Shing Knowledge Institute,St. Michael's Hospital,Toronto,Ontario,Canada.
International Psychogeriatrics
|June 1, 2017
Summary
Psychotic symptoms may be more common in prodromal dementia (PrD) than previously believed and can negatively impact the clinical course. Further research is needed to understand the role of psychosis in PrD.
Area of Science:
- Neuroscience
- Psychiatry
- Gerontology
Background:
- Neuropsychiatric symptoms (NPS) are linked to dementia progression.
- Mood and anxiety symptoms are common NPS in prodromal dementia (PrD).
- Psychotic symptoms in PrD have been understudied.
Purpose of the Study:
- To review the literature on psychosis in prodromal dementia (PrD).
- To examine the epidemiology, phenomenology, clinical course, and treatment of psychosis in PrD.
- To highlight the need for further research on psychosis in PrD.
Main Methods:
- Literature review of existing studies on psychosis in PrD.
- Inclusion of early and late-onset functional psychosis.
- Focus on epidemiological, phenomenological, and clinical aspects.
Main Results:
- Psychotic symptoms may be more prevalent in PrD than previously thought.
- Psychosis in PrD might be associated with a worse prognosis (mortality, dementia conversion).
- Heterogeneity in PrD studies and lack of late-onset psychosis patients contribute to variability.
Conclusions:
- Psychosis in PrD appears more common and impactful than recognized.
- Future research should include late-onset psychosis and focus on early intervention.
- Understanding psychosis in PrD is crucial for improving patient outcomes.
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