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Related Experiment Videos

beta-lactamases in bacteroides.

C E Nord, B Olsson, K Dornbusch

    Scandinavian Journal of Infectious Diseases. Supplementum
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Bacteroides fragilis causes most anaerobic infections and often resists beta-lactam antibiotics due to beta-lactamase production. This enzyme primarily exhibits cephalosporinase activity, contributing to treatment challenges.

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    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Pharmacology

    Background:

    • Bacteroides fragilis is a primary cause of anaerobic infections in humans.
    • Many B. fragilis isolates exhibit resistance to beta-lactam antibiotics.
    • Antibiotic resistance in B. fragilis may stem from beta-lactamase production or cell wall permeability issues.

    Purpose of the Study:

    • To investigate the mechanisms of beta-lactam antibiotic resistance in Bacteroides fragilis.
    • To characterize the biochemical properties of beta-lactamase produced by B. fragilis.
    • To compare beta-lactamase activity among different Bacteroides species.

    Main Methods:

    • Isolation and identification of Bacteroides species from clinical samples.
    • Antimicrobial susceptibility testing against beta-lactam antibiotics.

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  • Biochemical assays to detect and characterize beta-lactamase activity, including substrate specificity analysis.

    • Main Results:

    • Bacteroides fragilis isolates frequently demonstrated resistance to beta-lactam antibiotics.
    • Beta-lactamase production was identified as a key mechanism of resistance in B. fragilis.
    • The predominant beta-lactamase activity observed was cephalosporinase.
    • Other Bacteroides species (B. clostridiformis, B. melaninogenicus, B. oralis) also produced beta-lactamases, but with distinct biochemical profiles.

    Conclusions:

    • Beta-lactamase production, particularly cephalosporinase activity, is a significant factor in the resistance of Bacteroides fragilis to beta-lactam antibiotics.
    • Understanding the specific beta-lactamases produced by B. fragilis is crucial for guiding antimicrobial therapy.
    • Variations in beta-lactamase characteristics among Bacteroides species highlight the need for species-specific diagnostic and therapeutic approaches.