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Related Experiment Video

Updated: Dec 22, 2025

Author Spotlight: Insights into an Efficient Murine Maxillary Orthodontic Model Protocol

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Published on: October 27, 2023

MSX1 is differentially expressed in the deepest impacted maxillary third molars.

B Olsson¹, R D Calixto¹, N C da Silva Machado¹

¹Department of Stomatology, Department of Oral and Maxillofacial Surgery, Federal University of Paraná, Av. Prefeito Lothário Meissner, 632, Jardim Botânico, Curitiba, PR, 80210-170, Brazil.

The British Journal of Oral & Maxillofacial Surgery

|May 9, 2020

Summary

The expression of msh homeobox 1 (MSX1) differs based on the impaction depth of maxillary third molars. RUNX2 and BMP2 gene expression showed no significant differences related to impaction classifications.

Keywords:

Gene expression MSX1 impacted tooth third molar transcription factor

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Area of Science:

Oral and Maxillofacial Surgery
Molecular Biology
Dental Genetics

Background:

Impacted third molars are common dental anomalies, influenced by factors like space, eruption timing, tooth bud position, and genetics.
Understanding the molecular mechanisms behind impaction is crucial for predicting and managing these conditions.

Purpose of the Study:

To investigate differential gene expression of RUNX2, BMP2, and MSX1 in impacted third molars.
To correlate gene expression with impaction classifications (Winter's, Pell & Gregory) and tooth position.

Main Methods:

Gene expression analysis of RUNX2, BMP2, and MSX1 in bone samples from 32 patients undergoing surgical removal of impacted third molars.
Classification of impaction using orthopantomograms based on Winter's and Pell & Gregory's systems.
Statistical analysis including Kruskal-Wallis, Dunn's post hoc, and Spearman's correlation tests.

Main Results:

No significant correlations were found between the expression of RUNX2, BMP2, and MSX1.
No differences in gene expression were observed between maxillary and mandibular molars or according to Winter's or Pell & Gregory's classifications.
MSX1 gene expression was significantly different based on the depth of impaction in maxillary third molars (p=0.029).

Conclusions:

MSX1 gene expression is associated with the depth of impaction specifically in maxillary third molars.
RUNX2 and BMP2 gene expression do not appear to be significantly influenced by the impaction classifications studied.