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Related Experiment Video

Updated: Mar 1, 2026

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS
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[Multiple sclerosis fatigue, its neural correlates, and its modulation with tDCS].

Samar S Ayache1,2,3, Moussa A Chalah1,2, Tania Kümpfel4

  • 1EA 4391 Excitabilité Nerveuse et Thérapeutique, Université Paris-Est.

Fortschritte Der Neurologie-Psychiatrie
|June 1, 2017
PubMed
Summary

Multiple sclerosis (MS) fatigue mechanisms remain unclear, impacting quality of life. This review explores brain changes linked to MS fatigue and how transcranial direct current stimulation (tDCS) may help manage symptoms.

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Area of Science:

  • Neuroscience
  • Neurology
  • Clinical Medicine

Background:

  • Multiple sclerosis (MS) is a chronic central nervous system inflammatory disease causing significant disability.
  • Fatigue is a prevalent and debilitating symptom in MS patients, severely impacting their quality of life.
  • The exact pathophysiological mechanisms underlying MS fatigue are not fully understood, with complex multifactorial origins.

Purpose of the Study:

  • To review the neuronal correlates of fatigue in multiple sclerosis.
  • To discuss the potential of non-invasive brain stimulation, specifically transcranial direct current stimulation (tDCS), in modulating MS fatigue.

Main Methods:

  • Literature review focusing on radiological, physiological, and endocrine data related to MS fatigue.
  • Examination of studies investigating structural and functional changes in neuronal networks associated with fatigue.
  • Analysis of existing research on the application and efficacy of tDCS in modulating brain function and MS symptoms.

Main Results:

  • Fatigue in MS is hypothesized to involve structural and functional alterations across various neuronal networks.
  • Non-invasive brain stimulation techniques, like tDCS, show potential in modulating brain connectivity and function.
  • Current evidence for tDCS in MS fatigue is limited due to the preliminary nature of conducted studies.

Conclusions:

  • Understanding the neuronal basis of MS fatigue is crucial for developing effective interventions.
  • tDCS presents a promising avenue for future research and therapeutic strategies targeting MS-related fatigue.
  • Further rigorous studies are needed to establish the efficacy and safety of tDCS for managing fatigue in multiple sclerosis.