Related Experiment Video

Updated: Mar 1, 2026

Tissue Engineering of the Intestine in a Murine Model
08:45

Tissue Engineering of the Intestine in a Murine Model

Published on: December 1, 2012

15.6K

Long-term Outcomes in Intestinal Rehabilitation in Children

Danielle Wendel1, Simon P Horslen1

  • 1Department of Pediatric Gastroenterology and Hepatology, Seattle Children's Hospital, Seattle, WA.

Clinical Transplants
|June 1, 2017
PubMed

Insights

Advances in parenteral nutrition and multidisciplinary intestinal rehabilitation teams have improved survival rates for pediatric intestinal failure patients. This progress has reduced complications and identified factors predicting recovery, enhancing long-term outcomes.

Area of Science:

  • Pediatric Gastroenterology
  • Intestinal Rehabilitation
  • Parenteral Nutrition Management

Background:

  • Pediatric intestinal failure presents complex long-term challenges.
  • Advances in parenteral nutrition and supportive care are crucial.
  • Multidisciplinary intestinal rehabilitation teams are key to improving outcomes.

Purpose of the Study:

  • To review the long-term outcomes for pediatric patients with intestinal failure.
  • To highlight the impact of advancements in parenteral nutrition and intestinal rehabilitation.
  • To identify factors influencing recovery and long-term management.

Main Methods:

  • Review of recent advancements in the management of pediatric intestinal failure.
  • Analysis of survival rates, complication reduction, and quality of life.
  • Identification of predictive factors for parenteral nutrition duration and enteral autonomy.

Main Results:

  • Significant improvements in overall and transplant-free survival rates.
  • Decreased incidence of central line infections and liver disease.
  • Identification of factors predicting duration of parenteral nutrition and time to enteral autonomy.
  • Commonality of growth and developmental abnormalities requiring monitoring.

Conclusions:

  • Multidisciplinary intestinal rehabilitation and improved parenteral nutrition management have enhanced pediatric intestinal failure outcomes.
  • Long-term monitoring for growth and development is essential.
  • Future focus should include improving the quality of life for affected children and their families.

Keywords:
intestinal failureparenteral nutritionsurvival

More Related Videos

Murine Ileocolic Bowel Resection with Primary Anastomosis08:49

Murine Ileocolic Bowel Resection with Primary Anastomosis

Published on: October 29, 2014

17.5K
A Rat Graft Rejection Model of Intestinal Transplantation with Exteriorized Ileostomy for Longitudinal Prognosis Assessment08:25

A Rat Graft Rejection Model of Intestinal Transplantation with Exteriorized Ileostomy for Longitudinal Prognosis Assessment

Published on: June 10, 2025

595

Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
780
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
976
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
855
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding01:15

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding

Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
1.3K
Anatomy of the Intestines01:23

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
88.7K
Classification of Illness01:17

Classification of Illness

The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
9.1K