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Diabetic Neuropathy

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...

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Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies

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MR Micro-Neurography and a Segmentation Protocol Applied to Diabetic Neuropathy.

P F Felisaz¹, G Maugeri¹, V Busi¹

¹Radiology Department, University of Pavia, Pavia, Italy.

Radiology Research and Practice

|June 2, 2017

Summary

This summary is machine-generated.

Magnetic Resonance (MR) micro-neurography reveals structural nerve changes in diabetic peripheral neuropathy (DPN). This non-invasive imaging detects increased epineurium and nerve volume in DPN patients, aiding diagnosis.

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Area of Science:

Neurology
Radiology
Diabetology

Background:

Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus.
DPN affects nerve structure and function, leading to significant morbidity.
Current diagnostic methods for DPN often lack sensitivity to early structural changes.

Purpose of the Study:

To assess morphometric ultrastructural nerve changes in DPN using MR micro-neurography.
To quantify internal nerve component volumes and cross-sectional areas in DPN patients.
To evaluate the utility of MR micro-neurography for non-invasive DPN assessment.

Main Methods:

MR micro-neurography imaging protocol applied to tibial nerves.
Semiautomated tissue segmentation for measuring epineurium and fascicle volumes.
Comparison of nerve volume (NV), fascicle volume (FV), fascicle-to-nerve ratio (FNR), and cross-sectional area (CSA) between DPN patients and healthy controls.

Main Results:

DPN patients exhibited increased nerve volume (NV) and cross-sectional area (CSA).
A decreased fascicle-to-nerve ratio (FNR) was observed in DPN, attributed to epineural thickening.
Increased fascicle volume (FV) was noted in moderate to severe DPN cases.

Conclusions:

MR micro-neurography effectively visualizes and quantifies structural nerve alterations in DPN.
This non-invasive technique offers a valuable alternative to invasive nerve biopsy for DPN evaluation.
MR micro-neurography shows promise for studying microscopic changes in diabetic tibial nerves.