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Melanotic neuroectodermal tumor of infancy.

C H Lee1, S P Hong, C Y Lim

  • 1Department of Oral Pathology, College of Dentistry, Seoul National University.

Journal of Korean Medical Science
|September 1, 1986
PubMed
Summary

A rare melanotic neuroectodermal tumor of infancy (MNTI) was found in a 3-month-old Korean infant. This tumor presented as a bluish mass on the right maxillary alveolar ridge, causing tooth displacement.

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Area of Science:

  • Pediatric Oncology
  • Oral Pathology
  • Developmental Biology

Background:

  • Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, benign, but locally aggressive neoplasm.
  • It predominantly affects infants, typically within the first year of life.
  • MNTI most commonly occurs in the maxilla, followed by the mandible and cranial bones.

Observation:

  • A 3-month-old female infant presented with a bluish enlargement of the right maxillary alveolar mucosa.
  • The enlargement caused displacement of the deciduous central incisor.
  • Clinical examination revealed a rapidly growing mass.

Findings:

  • Gross examination showed a well-circumscribed, bluish-black mass.
  • Microscopic examination revealed biphasic pattern with nests of large epithelioid cells and smaller dark cells.
  • Ultrastructural studies confirmed the neural crest origin of the tumor cells.

Implications:

  • This case represents the first reported instance of MNTI in a Korean infant.
  • Early diagnosis and surgical management are crucial for favorable outcomes.
  • Further research is needed to understand the etiology and genetic factors of MNTI.

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