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Neurotensin binds with high affinity to small cell lung cancer cells
A E Allen1, D N Carney, T W Moody
1Department of Biochemistry, George Washington University School of Medicine and Health Sciences, Washington, DC 20037.
Peptides
|January 1, 1988
Abstract:
Several small cell lung cancer cell lines bound 125I-neurotensin with high affinity. Radiolabeled neurotensin bound with high affinity (Kd = 4 nM) to a single class of sites (2300/cell) using cell line NCI-H209. Binding was time dependent and reversible. Pharmacology studies indicated that the C-terminal of neurotensin was important for the high affinity binding activity. Because high concentrations of neurotensin and its receptors are associated with small cell lung cancer, neurotensin may function as a regulatory peptide in this disease.