Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

2.2K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.2K
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

2.8K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
2.8K
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

691
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
691
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

244
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
244
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

302
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
302
Neural Regulation01:37

Neural Regulation

43.8K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanistic Insights into the Role of Artificial Intelligence and Machine Learning in the Diagnosis and Management of Multiple Sclerosis.

Pathophysiology : the official journal of the International Society for Pathophysiology·2026
Same author

From rodents to algorithms: The rise of virtual animals in drug development and neuroscience.

Clinical neurology and neurosurgery·2025
Same author

Correction to: The Human Gut Microbiota: A Dynamic Biologic Factory.

Advances in biochemical engineering/biotechnology·2024
Same author

The Human Gut Microbiota: A Dynamic Biologic Factory.

Advances in biochemical engineering/biotechnology·2024
Same author

Leptomeningeal Metastatic Prostate Cancer Imitating a Subdural Hematoma.

Cureus·2022
Same author

Nanoparticle-Encapsulated Bryostatin-1 Activates α-Secretase and PKC Isoforms In vitro and Facilitates Acquisition and Retention of Spatial Learning in an Alzheimer's Disease Mouse Model.

Current Alzheimer research·2021

Related Experiment Video

Updated: Mar 1, 2026

Lipidomics and Transcriptomics in Neurological Diseases
09:58

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

4.1K

Liver Disease and Neurology.

Robert N Schwendimann, Alireza Minagar

    Continuum (Minneapolis, Minn.)
    |June 2, 2017
    PubMed
    Summary

    Neurologists must recognize nervous system symptoms in liver disease patients for timely diagnosis and treatment. Early detection of hepatic encephalopathy and Wilson disease is crucial for effective management.

    Area of Science:

    • Neurology
    • Hepatology
    • Neuroscience

    Background:

    • Liver disease significantly impacts the nervous system, affecting the brain, spinal cord, and peripheral nerves.
    • Neurologists must be aware of these associations, especially when patients present with altered cognition or consciousness.
    • Wilson disease, though rare, presents with diverse neurological and psychiatric symptoms and is treatable.

    Observation:

    • Hepatic encephalopathy can be identified through clinical suspicion and neuropsychological testing.
    • Severe hepatic encephalopathy in acute liver failure requires specialized neurocritical care.
    • Next-generation genetic testing offers a new diagnostic avenue for suspected Wilson disease.

    Findings:

    • The link between neurological manifestations and hepatocerebral degeneration is increasingly acknowledged.

    More Related Videos

    Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
    08:41

    Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

    Published on: March 24, 2023

    1.9K
    Human Liver Spheroids from Peripheral Blood for Liver Disease Studies
    09:51

    Human Liver Spheroids from Peripheral Blood for Liver Disease Studies

    Published on: January 27, 2023

    2.3K

    Related Experiment Videos

    Last Updated: Mar 1, 2026

    Lipidomics and Transcriptomics in Neurological Diseases
    09:58

    Lipidomics and Transcriptomics in Neurological Diseases

    Published on: March 18, 2022

    4.1K
    Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
    08:41

    Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

    Published on: March 24, 2023

    1.9K
    Human Liver Spheroids from Peripheral Blood for Liver Disease Studies
    09:51

    Human Liver Spheroids from Peripheral Blood for Liver Disease Studies

    Published on: January 27, 2023

    2.3K
  • Viral hepatitis is also recognized for its association with various neurological disorders.
  • Prompt diagnosis and management decisions are vital for patients with liver disease-related neurological conditions.

    • Implications:

    • Enhanced awareness among neurologists can lead to earlier diagnosis of neurological complications of liver disease.
    • Improved diagnostic tools, including genetic testing, can aid in identifying treatable conditions like Wilson disease.
    • Integrated care approaches are essential for managing the complex interplay between liver and nervous system disorders.