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Related Concept Videos

Esophageal Perforation-II: Clinical Manifestations and Management01:28

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Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
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Toxidromes: Clinical Features01:30

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Toxidromes are specific patterns of symptoms resulting from toxic substance exposure. They help in the identification and treatment of poisoning. The symptoms of each toxidrome group indicate poisoning by a certain class of chemicals or drugs.1. Sympathomimetic: Stimulates the sympathetic nervous system. Symptoms include agitation, increased heart rate (HR), blood pressure (BP), respiratory rate (RR), temperature, and pupil size. Drugs like cocaine and amphetamines, along with tremors and...
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Esophageal Strictures-II: Clinical Features and Management01:26

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Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
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Acute Pharyngitis01:30

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Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
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Acute Respiratory Failure-IV01:23

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Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...
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Pleural Effusion II: Symptoms and Management01:28

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Pleural Effusion Overview
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Related Experiment Video

Updated: Mar 1, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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CLOVES Syndrome: Severe Neonatal Presentation.

Silvana Acosta1, Viviana Torres2, María Paulos3

  • 1Assistant Professor, Department of Plastic Surgery Section, Surgery Division, Medical School, Pontificia Universidad Católica de Chile, Santiago, Santiago, Chile.

Journal of Clinical and Diagnostic Research : JCDR
|June 3, 2017
PubMed
Summary
This summary is machine-generated.

Congenital Lipomatous Overgrowth, Vascular Malformations, Epidermal Nevi and Spinal Abnormalities (CLOVES syndrome) is a rare neonatal overgrowth disorder. Extensive vascular malformations in newborns with CLOVES syndrome can lead to fatal septic and hemodynamic complications.

Keywords:
LipodystrophyNeonatalVascular malformation

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A Modified Sonographic Algorithm for Image Acquisition in Life-Threatening Emergencies in the Critically Ill Newborn
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Area of Science:

  • Medical Genetics
  • Pediatric Pathology
  • Neonatology

Background:

  • Congenital Lipomatous Overgrowth, Vascular Malformations, Epidermal Nevi and Spinal Abnormalities (CLOVES syndrome) is a rare, recently described overgrowth disorder.
  • The clinical course and neonatal presentation of CLOVES syndrome are not well understood.
  • Not all signs of CLOVES syndrome are present at birth, necessitating a high index of suspicion.

Purpose of the Study:

  • To describe the clinical presentation of CLOVES syndrome in a cohort of neonates.
  • To investigate the relationship between vascular malformations and mortality in neonatal CLOVES syndrome.
  • To propose a clinical classification for CLOVES syndrome in the neonatal period.

Main Methods:

  • Retrospective review of three neonatal cases with CLOVES syndrome.
  • Analysis of clinical presentations, including physical examination findings and diagnostic imaging.
  • Correlation of clinical features with outcomes, focusing on mortality causes.

Main Results:

  • Three neonates with CLOVES syndrome presented with extensive vascular malformations.
  • All three neonates died due to septic and hemodynamic complications directly linked to vascular malformations.
  • Clinical features varied, highlighting the importance of recognizing subtle signs.

Conclusions:

  • CLOVES syndrome in neonates can be associated with severe, life-threatening vascular malformations.
  • Prompt recognition and management of complications are crucial for improving outcomes in neonatal CLOVES syndrome.
  • A proposed clinical classification may aid in standardized diagnosis and management.