Related Experiment Video

Updated: Mar 1, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.8K

AMP-activated Protein Kinase as a Drug Target in Chronic Kidney Disease

Soumaya Allouch1, Shankar Munusamy1,2

  • 1College of Pharmacy, Qatar University, PO Box 2713, Doha, Qatar.

Current Drug Targets
|June 3, 2017
PubMed
Abstract

Insights

AMP-activated protein kinase (AMPK) deficiency contributes to chronic kidney disease (CKD) by disrupting cellular balance. AMPK activation, potentially via metformin, shows promise for preventing and treating CKD.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Cellular Biology

Background:

  • Chronic kidney disease (CKD) affects millions globally, being a leading cause of death.
  • AMP-activated protein kinase (AMPK) is crucial for cellular energy balance.
  • CKD pathogenesis involves impaired AMPK activity, autophagy, mTOR, and ER stress, promoting kidney damage.

Purpose of the Study:

  • To review the nephroprotective effects of AMPK.
  • To explore AMPK as a therapeutic target for CKD prevention and treatment.

Main Methods:

  • Literature review focusing on AMPK's role in CKD.
  • Analysis of experimental and clinical evidence on AMPK activators.

Main Results:

  • AMPK modulates key pathways implicated in CKD, including epithelial-to-mesenchymal transition and apoptosis.
  • Pharmacological AMPK activators, like metformin, demonstrate renoprotective effects in studies.
  • Metformin has shown potential to improve clinical outcomes in CKD patients.

Conclusions:

  • AMPK plays a critical role in maintaining kidney health.
  • Targeting AMPK offers a promising therapeutic strategy for managing CKD.
Keywords:
AMP-activated protein kinaseapoptosisautophagychronic kidney diseaseendoplasmic reticulum stressepithelial- mesenchymal transitionmammalian target of rapamycinmetformin.

More Related Videos

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium08:46

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium

Published on: September 1, 2015

10.3K
Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

1.0K

Related Concept Videos

Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
544
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
865
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
397
cAMP-dependent Protein Kinase Pathways01:25

cAMP-dependent Protein Kinase Pathways

Cyclic Adenosine Monophosphate (cAMP) is an essential second messenger that activates protein kinase A (PKA) and regulates various biological processes. A single epinephrine molecule binds to GPCR and activates several heterotrimeric G proteins, each stimulating multiple adenylyl cyclase, amplifying the signal, and synthesizing large numbers of cAMP molecules. Small changes in cAMP concentration affect PKA activity. The binding of four cAMP molecules induces a conformational change in PKA,...
8.7K
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
415
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
489