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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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Spotlight on landmark oncology trials: the latest evidence and novel trial designs

Helena Earl1, Stefano Molica2, Piotr Rutkowski3

  • 1University of Cambridge Department of Oncology, NIHR Cambridge Biomedical Research Centre, and Hon Consultant in Medical Oncology, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK.

BMC Medicine
|June 3, 2017
PubMed

Insights

Precision oncology and immunotherapy are transforming cancer treatment, with landmark trials guiding new targeted therapies. These advancements offer hope for patients with advanced cancers and high-risk disease.

Area of Science:

  • Oncology
  • Clinical Trials
  • Immunotherapy

Background:

  • Precision oncology has achieved significant success in treating advanced soft tissue sarcomas, breast cancer, ovarian cancer, and hematological neoplasms.
  • Immune checkpoint inhibitors show efficacy in adjuvant settings for melanoma, non-small cell lung carcinoma, and head and neck cancers.

Discussion:

  • Novel Phase II trials are crucial for accelerating the adoption of targeted cancer therapies.
  • These trials are designed to potentially become future landmark trials, shaping clinical practice.

Key Insights:

  • Recent clinical trials highlight the growing impact of immunotherapy in various cancer types.
  • The development of targeted therapies is rapidly evolving the oncological landscape.

Outlook:

  • Continued research and design of innovative clinical trials are essential for advancing cancer care.
  • A special collection in BMC Medicine focuses on practice-changing oncology trials.
Keywords:
CancerClinical trialsOncologyRandomised trialsTargeted therapyTrial design

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