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Updated: Mar 1, 2026
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Roux-en-Y Gastric Bypass Operation in Rats
Published on: June 11, 2012
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Urinary sodium excretion after gastric bypass surgery
Neil G Docherty1, Lars Fändriks2, Carel W le Roux3
1Department of Gastrosurgical Research & Education, Institute of Clinical Sciences Sahlgrenska Academy at University of Gothenburg Sahlgrenska University Hospital, Gothenburg, Sweden; Diabetes Complications Research Centre, Conway Institute, School of Medicine, University College Dublin, Dublin, Ireland.
Summary
Roux-en-Y gastric bypass surgery increases urinary sodium excretion and pro-B-type natriuretic peptide (NT-proBNP) levels, suggesting an enhanced gut-kidney signal contributes to blood pressure reduction.
Area of Science:
- Endocrinology
- Nephrology
- Bariatric Surgery
Background:
- Gut-kidney signaling influences sodium balance and blood pressure regulation.
- Roux-en-Y gastric bypass (RYGB) surgery effectively lowers blood pressure and promotes weight loss.
Purpose of the Study:
- To determine if RYGB intrinsically alters urinary sodium excretion.
- To investigate the role of altered sodium excretion in RYGB's blood pressure-lowering effects.
Main Methods:
- Five non-comorbid female patients underwent 24-hour assessments before and at multiple time points after RYGB.
- Urinary sodium excretion, creatinine clearance, and estimated glomerular filtration rate were calculated.
- Plasma NT-proBNP levels were measured pre- and post-meal.
Main Results:
- Weight-normalized urinary sodium excretion increased up to 2.3-fold by 20 months post-RYGB.
- Median fractional sodium excretion doubled, and NT-proBNP levels showed sustained or increased basal and postprandial elevations.
- These changes coincided with significant blood pressure reduction.
Conclusions:
- RYGB increases renal fractional sodium excretion.
- Elevated NT-proBNP levels post-RYGB correlate with increased sodium excretion.
- An enhanced natriuretic gut-kidney signal is a potential mechanism for RYGB-induced hypotension.
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