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Myocarditis in auto-immune or auto-inflammatory diseases
Cloé Comarmond1, Patrice Cacoub1
1Département de Médecine Interne et Immunologie Clinique, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier Pitié-Salpêtrière, F-75013 Paris, France; Département Hospitalo-Universitaire I2B, UPMC Univ Paris 06, F-75013 Paris, France; INSERM, UMR 7211, F-75005 Paris, France; CNRS, UMR 7211, F-75005 Paris, France; INSERM, UMR_S 959, F-75013 Paris, France.
Autoimmunity Reviews
|June 3, 2017
Summary
Myocarditis, a heart condition in young people, can lead to heart failure. Autoimmune diseases may involve myocarditis, but more research is needed for targeted immune therapies.
Area of Science:
- Cardiology
- Immunology
- Rheumatology
Background:
- Myocarditis is a significant cause of heart disease in young individuals.
- It frequently precedes the development of dilated cardiomyopathy and heart failure.
- Autoimmune and auto-inflammatory conditions like sarcoidosis and lupus erythematosus can be associated with myocarditis.
Purpose of the Study:
- To highlight the association between myocarditis and various autoimmune/auto-inflammatory diseases.
- To emphasize the scarcity of data regarding myocarditis in these specific patient groups.
- To advocate for the development of targeted immunomodulatory therapies for myocarditis.
Main Methods:
- Literature review on myocarditis and autoimmune diseases.
- Analysis of existing data on myocarditis prevalence in specific autoimmune conditions.
- Synthesis of current understanding and identification of knowledge gaps.
Main Results:
- Myocarditis is linked to several autoimmune and auto-inflammatory diseases.
- Data on myocarditis in these conditions are limited.
- Current therapeutic approaches may not be sufficiently tailored.
Conclusions:
- Further research is crucial to understand myocarditis in autoimmune diseases.
- Therapeutic strategies require precise immune system modulation based on disease type and phase.
- Personalized treatment approaches are needed for better patient outcomes.
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