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Thyrotoxicosis - investigation and management 

Jackie Gilbert1

  • 1King's College Hospital, Denmark Hill, London jackiegilbert@nhs.net.

Clinical Medicine (London, England)
|June 3, 2017
PubMed

Graves' disease (GD) and toxic nodular (TN) goitre account for most cases of thyrotoxicosis associated with hyperthyroidism. Hyperthyroidism is confirmed with measurement of a suppressed serum thyrotropin concentration (TSH) and elevated free thyroid hormones. The three therapeutic options are antithyroid drugs, radioactive iodine and surgery. Thionamides achieve long-term remission in 35% of cases. Many centres administer fixed doses of iodine-131; larger doses result in improved rates of cure at the cost of hypothyroidism. Surgery is usually considered for patients who have a large goitre, compressive symptoms or significant ophthalmopathy.

Keywords:
Grave’s diseaseradioiodinethionamidesthyroidectomythyrotoxicosis

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