Related Experiment Video

Updated: Mar 1, 2026

Generation and Expansion of Human Cardiomyocytes from Patient Peripheral Blood Mononuclear Cells
05:38

Generation and Expansion of Human Cardiomyocytes from Patient Peripheral Blood Mononuclear Cells

Published on: February 12, 2021

4.8K

Human heart disease: lessons from human pluripotent stem cell-derived cardiomyocytes

E Giacomelli1, C L Mummery1,2, M Bellin3

  • 1Department of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands.

Cellular and Molecular Life Sciences : CMLS
|June 3, 2017
PubMed
Summary

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) are valuable in vitro models for studying heart disease. These models accurately reflect human cardiac pathophysiology and drug responses, aiding therapeutic target discovery.

Keywords:
Cardiac arrhythmiaCardiac diseaseCardiomyopathyCardiovascular diseaseDisease modelingDrug screeningHuman pluripotent stem cell-derived cardiomyocytesSafety pharmacology

More Related Videos

Generation of Human Cardiomyocytes: A Differentiation Protocol from Feeder-free Human Induced Pluripotent Stem Cells13:18

Generation of Human Cardiomyocytes: A Differentiation Protocol from Feeder-free Human Induced Pluripotent Stem Cells

Published on: June 28, 2013

22.2K
Efficient Derivation of Human Cardiac Precursors and Cardiomyocytes from Pluripotent Human Embryonic Stem Cells with Small Molecule Induction10:46

Efficient Derivation of Human Cardiac Precursors and Cardiomyocytes from Pluripotent Human Embryonic Stem Cells with Small Molecule Induction

Published on: November 3, 2011

20.8K

Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.5K