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Developing a Rat Model for Bipolar Disorder
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Potential biomarkers for bipolar disorder: Where do we stand?
Rajesh Sagar1, Raman Deep Pattanayak1
1Department of Psychiatry, All Institute of Medical Sciences, New Delhi, India.
The Indian Journal of Medical Research
|June 3, 2017
Summary
Biomarkers for bipolar disorder (BD) are crucial for objective diagnosis. Promising neuroimaging, peripheral, and genetic markers are being explored to improve patient outcomes and advance personalized psychiatric medicine.
Area of Science:
- Psychiatry
- Neuroscience
- Genetics
Background:
- Bipolar disorder (BD) is a severe mood disorder with high morbidity and mortality.
- Current diagnosis relies on subjective methods, leading to potential misdiagnosis and poor outcomes.
- First-degree relatives of BD patients have an elevated risk of mood disorders.
Purpose of the Study:
- To critically appraise and update the status of promising biomarkers for bipolar disorder.
- To explore neuroimaging, peripheral, and genetic markers as potential diagnostic and prognostic tools.
- To discuss cognitive endophenotypes as indicators of genetic risk in BD.
Main Methods:
- Review of current literature on biomarkers for bipolar disorder.
- Appraisal of neuroimaging, peripheral, and genetic markers.
- Discussion of cognitive endophenotypes.
Main Results:
- No single biomarker is currently available due to BD's heterogeneity.
- Neuroimaging, peripheral biomarkers, and genetic markers show promise.
- Cognitive endophenotypes may indicate genetic predisposition.
Conclusions:
- Biomarkers are essential for objective validation in BD diagnosis.
- Translating research from 'bench to bedside' is key for clinical utility.
- Biomarkers will facilitate personalized medicine in psychiatry for bipolar disorder patients.
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