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Three-Stream, Bicarbonate-Based Hemodialysis Solution Delivery System Revisited: With an Emphasis on Some Aspects of
Susie Q Lew1, Orly F Kohn2, Yuk-Lun Cheng3
1Department of Medicine, George Washington University, Washington, DC.
Artificial Organs
|June 3, 2017
Summary
Hemodialysis patients receive buffer base from dialysis fluid concentrates. Organic anions in concentrates can convert to bicarbonate, impacting buffering power and patient treatment.
Area of Science:
- Nephrology
- Biochemistry
Background:
- Hemodialysis requires careful management of acid-base balance.
- Dialysis solutions provide buffering agents to correct metabolic acidosis.
Purpose of the Study:
- To review the buffering potential of organic anions in bicarbonate-based dialysis concentrates.
- To inform physicians about bicarbonate precursors in dialysis fluids.
Main Methods:
- Comparative analysis of acetic acid versus sodium diacetate in dialysis concentrates.
- Review of the metabolic conversion of organic anions to bicarbonate.
Main Results:
- Organic anions like acetate, citrate, and lactate can be converted to bicarbonate in the body.
- Different concentrate systems offer varying potential buffering capacities.
Conclusions:
- Physicians should understand the buffering contribution of organic anions in dialysis concentrates.
- This knowledge aids in optimizing bicarbonate delivery and acid-base management for hemodialysis patients.
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