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Updated: Mar 1, 2026
05:31
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
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[IMMUNE RESPONSE IN CHRONIC BRONCHIOLITIS OBLITERANS IN CHILDREN]
I Mustafayev1, L Allahverdyeva1, A Bogdanova1
11Research Institute of Lung Diseases, Baku; 2State Medical University, Baku, Azerbaijan; 3Research Institute of Pulmonology of The Pavlov First Saint Petersburg State Medical University, Sankt-Petersburg, Russia.
Georgian Medical News
|June 3, 2017
Summary
Children with bronchiolitis obliterans show temporary immune changes during exacerbations, not true immunosuppression. Immune responses normalize during remission, indicating an adequate reaction to infection.
Area of Science:
- Pediatric Immunology
- Respiratory Medicine
- Infectious Diseases
Background:
- Bronchiolitis obliterans is a serious post-infectious airway disease in children.
- Understanding the immune system's role is crucial for managing this condition.
Purpose of the Study:
- To assess cellular and humoral immunity in children diagnosed with bronchiolitis obliterans.
- To differentiate between immune response and immunosuppression during disease exacerbation and remission.
Main Methods:
- Studied 139 children aged 2-14 years with bronchiolitis obliterans.
- Monitored immune parameters including immunoglobulin levels (IgA, IgM), circulating immune complexes, and cytokine profiles (interleukins).
- Compared immune status during acute exacerbation versus remission phases.
Main Results:
- Observed transient, minor immune alterations during exacerbations, including decreased IgA, increased IgM, and elevated circulating immune complexes.
- Detected significant increases in pro- and anti-inflammatory cytokines during the acute phase, normalizing in remission.
- Concluded that observed immune changes are adaptive responses to infection, not indicative of sustained immunosuppression.
Conclusions:
- Bronchiolitis obliterans involves dynamic immune system adjustments rather than a state of immunosuppression.
- Immune profiles normalize as inflammation subsides, reflecting a typical response to viral and bacterial triggers.
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