Vitamin D Deficiency and Supplementation in Cardiovascular Disorders

Cardiovascular disease (CVD) is the leading cause of death in developed countries. Similarly, the frequency of vitamin D deficiency is increasing, and a number of epidemiologic and clinical studies have suggested that there is an increased risk of CVD among people with depletion of this vitamin. This has raised much interest in the potential pathogenic and therapeutic role of vitamin D in CVD. However, randomized trials and meta-analyses have not shown a clear benefit of vitamin D supplementation with respect to cardiovascular events. Herein, we provide a comprehensive review of the most relevant evidence to date regarding vitamin D deficiency and supplementation, and their respective impact on CVD prevention and treatment.