[Research progress of neutrophil extracellular traps in septic coagulopathy]

Area of Science:

• Critical care medicine
• Hematology
• Immunology

Background:

• Sepsis-induced coagulopathy (SIC) is a severe complication in intensive care, linked to high mortality.
• Vascular endothelial cell injury and coagulation dysfunction are key pathological mechanisms in sepsis.
• Neutrophil extracellular traps (NETs) are implicated in various inflammatory and infectious diseases.

Purpose of the Study:

• To review the mechanistic role of NETs in the pathogenesis of SIC.
• To discuss the potential of NETs as diagnostic biomarkers for SIC.
• To explore NETs as therapeutic targets for managing SIC.

Main Methods:

• Literature review of studies investigating NETs and SIC.
• Analysis of mechanisms linking NETs to endothelial damage and coagulation imbalance.
• Synthesis of current research on NET-based diagnostics and therapeutics.

Main Results:

• NETs contribute to SIC by causing vascular damage and promoting immunothrombosis.
• NETs disrupt the balance between coagulation and fibrinolysis in sepsis.
• Evidence suggests NETs play a central role in SIC development.

Conclusions:

• NETs are crucial mediators in the development of sepsis-induced coagulopathy.
• NETs show promise as potential biomarkers for early diagnosis of SIC.
• Targeting NETs represents a potential therapeutic strategy for SIC.