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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
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LTA4H regulates cell cycle and skin carcinogenesis.

Naomi Oi1, Hiroyuki Yamamoto1, Alyssa Langfald1

  • 1The Hormel Institute, University of Minnesota, 801 16th Ave. NE, Austin, MN 55912, USA.

Carcinogenesis
|June 3, 2017
PubMed
Summary

Leukotriene A4 hydrolase (LTA4H) is overexpressed in skin cancer and drives tumor development by regulating the cell cycle. Depleting LTA4H halts cancer growth by inducing G0/G1 phase arrest and stabilizing the p27 protein.

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