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Accelerating Biomedical Discoveries through Rigor and Transparency.

Judith A Hewitt1, Liliana L Brown1, Stephanie J Murphy1

  • 1Office of Biodefense, Research Resources and Translational Research, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD. Office of Genomics and Advanced Technologies, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD. Division of Comparative Medicine, Office of Infrastructure Programs, Division of Program Coordination, Planning, and Strategic Initiatives, Office of the Director at the National Institutes of Health, Bethesda, MD. Office of Infrastructure Programs, Division of Program Coordination, Planning, and Strategic Initiatives, Office of the Director, National Institutes of Health, Bethesda, MD. National Institute of Neurological Disorders and Stroke, Bethesda MD.

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|June 3, 2017
PubMed
Summary
This summary is machine-generated.

The National Institutes of Health (NIH) implemented a policy in 2015 to improve research reproducibility and transparency. This policy aims to enhance the reliability and translational value of biomedical research, particularly in animal models.

Keywords:
animal modelsbiasqualificationqualityreproducibilityrigorstatisticstransparency

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Area of Science:

  • Biomedical Research
  • Research Integrity

Background:

  • Reproducibility challenges in published research are a significant concern.
  • The National Institutes of Health (NIH) identified low reproducibility as a critical issue in biomedical research funding.

Purpose of the Study:

  • To explain the NIH policy designed to enhance reproducibility through rigor and transparency.
  • To discuss the policy's impact on the translatability of research findings, especially those using animal models.

Main Methods:

  • Review of the factors leading to the NIH reproducibility policy.
  • Description of the policy's key elements, including resources for the research community.
  • Analysis of the policy's implications for research using animal models.

Main Results:

  • The policy aims to improve the rigor and transparency of research methodologies.
  • While potentially increasing near-term animal use, the policy promotes long-term efficiency and productivity.
  • Enhanced rigor in assessing variables and data is expected to improve the translational value of animal studies.

Conclusions:

  • The NIH policy on rigor and transparency is expected to increase the reliability and efficiency of biomedical research.
  • Improved research practices will lead to better assessments of the translational potential of animal models.
  • Ultimately, the policy benefits the research community and society by advancing scientific understanding and application.