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Salivirus infection in children with diarrhea, Thailand

Kattareeya Kumthip1, Pattara Khamrin1, Arpaporn Yodmeeklin1

  • 1Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.

Archives of Virology
|June 4, 2017
PubMed

Insights

Salivirus, a novel picornavirus, was investigated in Thai children with gastroenteritis. The virus was detected in one child, marking the first report of salivirus infection in Thailand.

Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Background:

  • Salivirus (Klassevirus) is a recently identified picornavirus.
  • Its association with human gastroenteritis and epidemiology remain largely unknown.
  • Limited data exists on salivirus prevalence globally.

Purpose of the Study:

  • To investigate the prevalence of salivirus in children with acute gastroenteritis in Thailand.
  • To identify the specific genotype of salivirus detected.
  • To contribute to understanding the epidemiology of salivirus infections.

Main Methods:

  • Molecular screening of fecal samples from hospitalized children in Chiang Mai, Thailand (2015-2016).
  • Utilized reverse transcription-nested PCR (RT-nested PCR) for virus detection.
  • Genotyping based on nucleotide sequences of 5'UTR, VP1, and 3D regions.

Main Results:

  • Salivirus was detected in 1 out of 229 (0.44%) fecal samples.
  • The detected salivirus belonged to genotype A1.
  • This study provides the first evidence of salivirus infection in young children with acute diarrhea in Thailand.

Conclusions:

  • Salivirus infection occurs in young children with acute diarrhea in Thailand.
  • Genotype A1 is circulating in the Thai pediatric population.
  • Further epidemiological studies are needed to determine the clinical significance and broader impact of salivirus.

Keywords:
ChildrenDiarrheaGastroenteritisKlassevirusSalivirus

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