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Association Study of MMP-9 -1562C/T Gene Polymorphism with Susceptibility to Multiple Autoimmune Diseases: A

Jing Li1, Shuang-Yan Lin1, Yan-Bo Lv1

  • 1Department of Pathology, Zhejiang Hospital, Hangzhou, Zhejiang, China.

Archives of Medical Research
|June 5, 2017
PubMed
Abstract

Insights

The MMP-9 -1562 C/T gene polymorphism is linked to increased susceptibility to autoimmune diseases (ADs). This association is particularly notable in Caucasian populations and for various ADs, excluding multiple sclerosis.

Area of Science:

  • Genetics
  • Immunology
  • Molecular Biology

Background:

  • Matrix metalloproteinase-9 (MMP-9) gene polymorphism (-1562 C/T) is implicated in autoimmune diseases (ADs).
  • Previous studies on MMP-9 polymorphism and ADs have yielded inconsistent results.
  • A comprehensive meta-analysis is needed to clarify the association.

Purpose of the Study:

  • To evaluate the overall association between the MMP-9 -1562 C/T gene polymorphism and the susceptibility to multiple ADs.
  • To synthesize evidence from existing studies using a meta-analytic approach.

Main Methods:

  • Systematic literature search of PubMed, Embase, and Web of Science databases up to March 1, 2016.
  • Meta-analysis of 12 studies including 2,034 cases and 1,861 controls.
  • Calculation of odds ratios (ORs) and 95% confidence intervals (CIs) using fixed- or random-effect models based on heterogeneity.

Main Results:

  • A significant association was found between the MMP-9 -1562 T allele and AD susceptibility in the overall population (OR=1.269) and Caucasians (OR=1.222).
  • The association was significant for 'other ADs' (OR=1.501) but not for multiple sclerosis.
  • No significant association was observed in Asian populations or for multiple sclerosis.

Conclusions:

  • The MMP-9 -1562 C/T polymorphism may contribute to susceptibility to multiple ADs.
  • The association appears stronger in Caucasian populations and for a broader category of ADs.
  • Further large-scale epidemiological studies are recommended to validate these findings.
Keywords:
Autoimmune diseaseMatrix metalloproteinase-9Meta-analysisMultiple sclerosisPolymorphismSusceptibility

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