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Updated: Mar 1, 2026

Spatial Molecular Imaging of the Glycome Using Mass Spectrometry
Published on: November 28, 2025
Visualizing glycans on single cells and tissues-Visualizing glycans on single cells and tissues
Ben Ovryn1, Jie Li1, Senlian Hong1
1Department of Molecular Medicine, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, United States.
Abstract:
Metabolic oligosaccharide engineering and chemoenzymatic glycan labeling have provided powerful tools to study glycans in living systems and tissue samples. In this review article, we summarize recent advances in this field with a focus on innovative approaches for glycan imaging. The presented applications demonstrate that several of the leading imaging methods, which have revolutionized quantitative cell biology, can be adapted to imaging glycans on single cells and tissues.

