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Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein
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Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein

Published on: June 30, 2019

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The NDR/LATS protein kinases in immunology and cancer biology

Ahmad A D Sharif1, Alexander Hergovich1

  • 1Tumour Suppressor Signalling Networks Laboratory, UCL Cancer Institute, University College London, WC1E 6BT, London, United Kingdom.

Seminars in Cancer Biology
|June 6, 2017
PubMed

Insights

The NDR/LATS kinase family regulates cell growth and death. This review explores their roles in immunity and cancer, including activation, mouse models, and clinical relevance for cancer treatment.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Cancer Biology

Background:

  • The NDR (nuclear Dbf2-related)/LATS (large tumour suppressor) kinases are AGC group serine/threonine protein kinases.
  • They are crucial for cell proliferation, cell death, and tissue growth via the Hippo pathway (YAP/TAZ kinases).

Purpose of the Study:

  • To review the roles of mammalian NDR1/2 and LATS1/2 in immunity and cancer.
  • To discuss their activation mechanisms, knockout mouse models, and clinical significance in human cancers.

Main Methods:

  • Literature review focusing on NDR/LATS family kinases.
  • Analysis of activation pathways involving Ste20-like kinases and MOB1.
  • Examination of mutation and expression data in human cancers.

Main Results:

  • NDR/LATS kinases are implicated in immune responses and cancer development.
  • Activation involves specific kinase cascades and signal transducers.
  • Aberrant NDR/LATS expression and mutations are observed in various human cancers.

Conclusions:

  • NDR/LATS kinases are key regulators in cellular processes relevant to immunity and cancer.
  • Understanding their mechanisms and clinical status may offer predictive and prognostic value for cancer therapy.
Keywords:
AGC kinasesCancerImmunologyLarge tumour suppressor kinaseSTK38STK38LSerine/threonine protein kinasesnuclear Dbf2-related kinase

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