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Updated: Mar 1, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
Autotransfusion Cell-Saver and Plasma Saver
Roy L Tawes1, Thomas B DuVall1
1Peninsula Hospital Medical Center, Burlingame, California.
Abstract:
Early attempts at blood salvage during surgery shared many of the complications associated with the development of cardiopulmonary (heart-lung) bypass machines; especially, coagulopathy and air embolism. By the late 1970s, the technology had developed to the point where not only were the red blood cells salvaged, but washed and processed in a manner that prevented auto-immunisation, transfusion reactions, and transmission of diseases. Blood conservation became practical.
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