Decreased SIRT4 protein levels in endometrioid adenocarcinoma tissues are associated with advanced AJCC stage
Xiaoxi Chen1, Xiangwen Lai2, Caixia Wu3
1Department of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Background:
Members of the SIRT family are a highly conserved family of NAD+-dependent enzymes, many of which (SIRT1-7) play an important role in tumor formation. Recently, several studies have suggested that SIRT4 not only regulates glutamine metabolism, but also serves as a tumor suppressor. There are no studies have assessed its clinical significance in endometrioid adenocarcinoma.
Methods:
We investigated SIRT4 protein levels in endometrioid adenocarcinoma and its possible association with selected clinico-pathological parameters by immunohistochemical staining of a tissue microarray that included 65 endometrioid adenocarcinoma patients.
Results:
SIRT4 protein levels in endometrioid adenocarcinoma were markedly lower than its non-neoplastic tissue counterpart (P< 0.001). Moreover, lower SIRT4 expression levels were observed in advanced AJCC stages of development (P= 0.002).
Conclusions:
Our results indicated that SIRT4 may be involved in the development of endometrioid adenocarcinoma and is a promising target for both the diagnosis and potential therapy of endometrioid adenocarcinoma.
Insights
SIRT4 protein levels are significantly lower in endometrioid adenocarcinoma, suggesting its role as a tumor suppressor. This finding highlights SIRT4 as a potential diagnostic and therapeutic target for this cancer.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Sirtuins (SIRTs) are NAD+-dependent enzymes crucial in tumor formation.
- SIRT4 is implicated in glutamine metabolism and acts as a tumor suppressor.
- Clinical significance of SIRT4 in endometrioid adenocarcinoma remains unexamined.
Purpose of the Study:
- To investigate SIRT4 protein levels in endometrioid adenocarcinoma.
- To assess the association between SIRT4 expression and clinico-pathological parameters.
Main Methods:
- Immunohistochemical staining was performed on a tissue microarray.
- The study included 65 endometrioid adenocarcinoma patients and their non-neoplastic counterparts.
Main Results:
- SIRT4 protein levels were significantly lower in endometrioid adenocarcinoma compared to non-neoplastic tissue (P<0.001).
- Reduced SIRT4 expression correlated with advanced AJCC stages (P=0.002).
Conclusions:
- SIRT4 may play a role in endometrioid adenocarcinoma development.
- SIRT4 is a potential diagnostic and therapeutic target for endometrioid adenocarcinoma.
