Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metastasis02:30

Metastasis

6.7K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.7K
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

14.3K
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
14.3K
Bone Markings01:26

Bone Markings

8.5K
Bones have various surface features that help form joints and attach to other soft tissues. Depending on the function, bone markings are categorized into articulating projections, processes for attachment, depressions, and openings.
Articulating Projections
Articulating projections are found where two bones meet to form a joint. These structures are usually found at the ends of bones. The largest articulation is a rounded projection called the head, supported by a narrow neck at the ends of...
8.5K
Bone Remodeling01:40

Bone Remodeling

40.7K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.7K
Overview of the Axial Skeleton01:09

Overview of the Axial Skeleton

12.9K
The skeleton is subdivided into two major divisions—the axial skeleton and the appendicular skeleton. The axial skeleton forms the vertical, central axis of the body. It includes all of the bones of the head, neck, chest, and back. It protects the brain, spinal cord, heart, and lungs. It also serves as the attachment site for muscles that move the head, neck, and back and for muscles that act across the shoulder and hip joints to move their corresponding limbs.
The axial skeleton of the...
12.9K
Bone Disorders01:29

Bone Disorders

5.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex Differences in Depression: Adult Cytogenesis as Potential Target for Precision Psychiatry.

Cells·2026
Same author

Real-world healthcare resource use and costs associated with the management of locally advanced head and neck cancer in Portugal - TRACE2 study.

Frontiers in oncology·2026
Same author

Gravity Water Waves over Constant Vorticity Flows: From Laminar Flows to Touching Waves.

Water waves (Cham, Switzerland)·2026
Same author

Maternal infection in the context of actively managed prelabor rupture of membranes at term: An observational study.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2026
Same author

Impact of the 2023 ACR/EULAR classification criteria in pregnant women with primary antiphospholipid syndrome: insights from a Portuguese cohort.

ARP rheumatology·2026
Same author

Adult astrocyte generation across health and disease: A systematic review.

Neural regeneration research·2026

Related Experiment Video

Updated: Mar 1, 2026

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

3.3K

Bone Metastases: An Overview.

Filipa Macedo1, Katia Ladeira2, Filipa Pinho2

  • 1Medical Oncology Department, Portuguese Oncology Institute, Coimbra, Portugal.

Oncology Reviews
|June 7, 2017
PubMed
Summary

Bone metastases, common in breast and prostate cancer, are rarely curable but treatable. Advances in drugs and interventions improve patient quality of life and life expectancy, requiring a multidisciplinary approach.

Keywords:
Bone metastasisbisphosphonatesdenosumabfracturesradiotherapy

More Related Videos

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

43.3K
Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis
07:00

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis

Published on: September 26, 2016

17.6K

Related Experiment Videos

Last Updated: Mar 1, 2026

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

3.3K
Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

43.3K
Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis
07:00

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis

Published on: September 26, 2016

17.6K

Area of Science:

  • Oncology
  • Orthopedics
  • Radiology

Background:

  • Bone metastases are common in cancer patients, often indicating a poor prognosis.
  • Skeletal metastases are more frequent than primary bone cancers, particularly in adults.
  • Breast and prostate cancers are the most common causes of bone metastasis.

Purpose of the Study:

  • To review the types, clinical approach, and treatment of bone metastases.
  • To highlight the importance of a multidisciplinary approach in managing bone metastases.
  • To discuss recent advancements in improving quality of life and life expectancy for patients with bone metastases.

Main Methods:

  • Review of existing literature on bone metastases.
  • Analysis of diagnostic methods including signs, symptoms, and imaging.
  • Evaluation of current and emerging treatment strategies.

Main Results:

  • Bone metastases are a frequent complication of cancer, impacting prognosis.
  • Diagnosis relies on clinical presentation and advanced imaging techniques.
  • New therapeutic strategies significantly enhance patient quality of life and survival rates.

Conclusions:

  • Bone metastases necessitate a comprehensive, multidisciplinary treatment strategy.
  • While often incurable, bone metastases can be effectively managed to improve patient outcomes.
  • Ongoing research and therapeutic advancements offer improved life expectancy and quality of life for affected individuals.