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A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets
Ye-Jin Hwang1, Connor W Coley, Milad Abolhasani
1Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. kfjensen@mit.edu.
Chemical Communications (Cambridge, England)
|June 7, 2017
Abstract:
We report an automated flow chemistry platform that can efficiently perform a wide range of chemistries, including single/multi-phase and single/multi-step, with a reaction volume of just 14 μL. The breadth of compatible chemistries is successfully demonstrated and the desired products are characterized, isolated, and collected online by preparative HPLC/MS/ELSD.
