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Polydopamine nanocoated whole-cell asymmetric biocatalysts
Li Wang1, Zhi-Yi Hu, Xiao-Yu Yang
1State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, 122 Luoshi Road, 430074 Wuhan, China. xyyang@whut.edu.cn baoliansu@whut.edu.cn.
Chemical Communications (Cambridge, England)
|June 7, 2017
Summary
This study presents a whole-cell biocatalyst with a polydopamine nanocoating, demonstrating significantly enhanced catalytic activity and reusability for asymmetric reduction. The novel coating also enables multi-functionalization with various nanoparticles.
Area of Science:
- Biocatalysis
- Nanotechnology
- Chemical Engineering
Background:
- Whole-cell biocatalysts offer sustainable routes for chemical synthesis.
- Improving biocatalyst activity, reusability, and functionality is crucial for industrial applications.
- Polydopamine coatings provide a versatile platform for surface modification.
Purpose of the Study:
- To develop a highly active and reusable whole-cell biocatalyst using polydopamine nanocoating.
- To investigate the integration of polydopamine-coated biocatalysts with nanoparticles for multi-functionalization.
- To evaluate the performance of the modified biocatalyst in asymmetric reduction reactions.
Main Methods:
- Whole-cell biocatalyst preparation with polydopamine nanocoating.
- Asymmetric reduction reaction optimization and performance testing.
- Characterization of biocatalyst reusability and integration with titania, silica, and magnetic nanoparticles.
Main Results:
- The polydopamine-coated biocatalyst exhibited 5 times higher productivity compared to the native cell.
- The biocatalyst maintained 84% of its initial yield after 5 batches, showing 8 times higher reusability than the native cell.
- Successful integration with titania, silica, and magnetic nanoparticles was achieved, enabling multi-functionalization.
Conclusions:
- Polydopamine nanocoating significantly enhances the catalytic performance and reusability of whole-cell biocatalysts.
- The developed biocatalyst is a promising platform for efficient and sustainable asymmetric reduction.
- The multi-functionalization capability opens avenues for advanced biocatalytic systems.
