The Bony Side of Endothelial Cells in Prostate Cancer
1Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Developmental Cell
|June 7, 2017
Abstract:
Prostate cancer bone metastases are primarily osteoblastic, but the source of bone-forming cells in these lesions remains poorly defined. In this issue of Developmental Cell, Lin et al. (2017) demonstrate that tumor-associated endothelial cells can give rise to osteoblasts in prostate cancer through endothelial-to-osteoblast (EC-to-OSB) conversion.
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