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Biocompatible zwitterionic phosphorylcholine polymers with aggregation-induced emission feature.

Gaoyi Xie1, Chunping Ma2, Xiqi Zhang3

  • 1College of Chemical Engineering, Guizhou Institute of Technology, Guiyang, 550003, PR China.

Colloids and Surfaces. B, Biointerfaces
|June 7, 2017
PubMed
Summary

Novel zwitterionic phosphorylcholine polymers with aggregation-induced emission (AIE) were synthesized into fluorescent polymeric nanoparticles (FPNs). These biocompatible FPNs exhibit excellent water dispersibility, stability, and cytocompatibility, making them promising for biomedical applications.

Keywords:
Aggregation-induced emissionBiocompatibilityCritical micelle concentrationFluorescent polymeric nanoparticlesZwitterionic phosphorylcholine polymer

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Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Biomedical Engineering

Background:

  • Zwitterionic polymers offer unique properties for biomedical applications.
  • Aggregation-induced emission (AIE) materials provide enhanced fluorescence in aggregated states.
  • Developing biocompatible fluorescent nanoparticles is crucial for advanced imaging and diagnostics.

Purpose of the Study:

  • To synthesize novel zwitterionic polymers with AIE characteristics.
  • To fabricate fluorescent polymeric nanoparticles (FPNs) from these copolymers.
  • To evaluate the properties and biocompatibility of the FPNs for potential biomedical uses.

Main Methods:

  • Reversible addition fragmentation chain transfer polymerization was used to synthesize copolymers.
  • Characterization involved 1H NMR, FT-IR, and X-ray photoelectron spectroscopy.
  • Nanoparticle formation, size, morphology, dispersibility, fluorescence, stability, and cytotoxicity were assessed.

Main Results:

  • Two zwitterionic AIE polymers (MTP1 and MTP2) were successfully synthesized.
  • Amphiphilic copolymers self-assembled into spherical FPNs with sizes of 345±22nm (MTP1) and 147±36nm (MTP2).
  • FPNs demonstrated high water dispersibility, bright green fluorescence (45% quantum yield for MTP1), excellent particle stability, and high cytocompatibility.

Conclusions:

  • The synthesized zwitterionic AIE polymers can form stable, biocompatible fluorescent nanoparticles.
  • These FPNs exhibit promising properties for cell imaging and other biomedical applications.
  • The findings encourage further research into high-performance biocompatible fluorescent polymers for the biomedical field.