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Perturbations in the Replication Program Contribute to Genomic Instability in Cancer
Britny Blumenfeld1, Micha Ben-Zimra2,3, Itamar Simon4
1Department of Microbiology and Molecular Genetics, IMRIC, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel. britny.blumenfeld@mail.huji.ac.il.
International Journal of Molecular Sciences
|June 8, 2017
Summary
Errors in deoxyribonucleic acid (DNA) replication contribute to cancer and genomic instability. This review covers how replication stress and timing issues cause DNA replication inaccuracies, leading to mutations.
Area of Science:
- Molecular Biology
- Genetics
- Cancer Research
Background:
- Genomic instability is a hallmark of cancer.
- Deoxyribonucleic acid (DNA) replication fidelity is crucial for maintaining genomic stability.
- Errors in DNA replication can lead to mutations and structural variations, driving cancer development.
Purpose of the Study:
- To review the mechanisms underlying inaccuracies in the DNA replication program.
- To discuss the impact of these inaccuracies on cancer and genomic instability.
- To highlight the roles of replication stress and temporal organization aberrations.
Main Methods:
- Literature review of mechanisms and impact of DNA replication errors.
- Analysis of the relationship between replication fidelity and genomic instability.
- Synthesis of current knowledge on replication stress and timing.
Main Results:
- Inaccuracies in DNA replication arise from loss of fidelity during replication stress.
- Aberrations in the temporal organization of replication also contribute to errors.
- These replication errors increase the acquisition of mutations and structural variations.
Conclusions:
- Understanding DNA replication errors is key to addressing cancer and genomic instability.
- Replication stress and temporal organization are critical factors influencing replication fidelity.
- Targeting these mechanisms may offer new therapeutic strategies for cancer.
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