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Related Concept Videos

Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Trigger-Responsive Gene Transporters for Anticancer Therapy.

Santhosh Kalash Rajendrakumar1, Saji Uthaman2, Chong Su Cho3

  • 1Department of Biomedical Science and BK21 PLUS Center for Creative Biomedical Scientists at Chonnam National University, Chonnam National University Medical School, Gwangju 61469, Korea. kalash1288@gmail.com.

Nanomaterials (Basel, Switzerland)
|June 8, 2017
PubMed
Summary
This summary is machine-generated.

Trigger-responsive nanoparticles enhance gene delivery to cancer cells by overcoming limitations of traditional cationic transporters. These advanced systems utilize triggers like light or ultrasound for improved therapeutic outcomes.

Keywords:
anti-cancercationic polymergene deliveryglutathionemagnetic fieldnon-viralphotothermaltrigger-responsiveultrasound

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Area of Science:

  • Biotechnology and Nanomedicine
  • Cancer Therapeutics
  • Gene Delivery Systems

Background:

  • Cationic gene transporters (polyplexes, lipoplexes) are crucial for delivering nucleic acids (pDNA, mRNA, siRNA, miRNA) to cancer cells.
  • Gene transfer efficiency is influenced by multiple factors including cell binding, intracellular trafficking, endosomal escape, DNA unpacking, and nuclear transport.
  • Balancing these factors is critical, as some can adversely affect others, limiting current gene delivery strategies.

Purpose of the Study:

  • To review the mechanisms and limitations of traditional cationic gene transporters.
  • To explore the role of trigger-responsive nanoparticles in overcoming existing gene delivery challenges.
  • To discuss various triggers and their application in enhancing gene transfer efficiency for anticancer therapy.

Main Methods:

  • Review of existing literature on cationic gene transporters and trigger-responsive nanoparticle systems.
  • Analysis of mechanisms governing gene transfer efficiency and the impact of various triggers.
  • Discussion of challenges and future directions in the development of these nanocarriers.

Main Results:

  • Trigger-responsive nanoparticles offer potential solutions to the intrinsic drawbacks of conventional gene transporters.
  • Triggers such as light, enzymes, magnetic fields, and ultrasound (US) can significantly enhance gene transfer efficiency.
  • These advanced systems aim to optimize the complex cascade of events required for successful gene delivery.

Conclusions:

  • Trigger-responsive nanoparticles represent a promising advancement in targeted gene delivery for cancer therapy.
  • Further research and development are needed to address challenges and fully realize their therapeutic potential.
  • Optimized trigger-responsive systems are essential for improving the efficacy and safety of nucleic acid-based cancer treatments.